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Gayathri Publishers is a non profit company in India. The company have published 8 Journals in print and online, and open access, They are covering vast research areas of biological Sciences, Chemical sciences and Medical Sciences.   We have published quality of research articles and open source a lot of articles, to help in the young scholars, scientists and professors. All the free journals are Open Access Journals including Clinical, Medical, and Chemistry, Education, Pharmaceutical, Life Sciences, Environmental, Engineering and Management journals. It can be associated with any academic or scientific databases for greater visibility of the published articles. This open access format is one of the important models of publishing which has been widely appreciated, supported than the traditional toll access journals.

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Volume No 7(1)                                                                       April,2017

Brine Shrimp (Artemia salina) Toxicity Assay of selected medicinal plants in Tamil Nadu
 
M.Maridass and G. Raju

 

Abstract
 
The brine shrimp lethality bioassay is extensively used for the isolation of antitumour and cytotoxic agents from several medicinal plants. In the aim of the present study, to assess as cytotoxic activity of ethanolic extract of six species were Cinnamomum wightii Meisner, Garcinia gummi-gutta (L.) Robs., Michelia nilagrica Zenk. Tylophora indica (Burm. f.) Merr., Hemidesmus indicus (L.) R. Br. and Gymnema sylvestre (Retz.) R. Br. ex Schult using by brine shrimp lethality bioassay method. The results of the present study, maximum cytotoxic activity of both plants of Gymnema sylvestre and Michelia nilagrica ethanolic extracts were observed. The highest activity was found for ethanolic extract of Gymnema sylvestre and Michelia nilagrica with LC50 value of 0.56 and 0.89µg/ml respectively. These results suggest that the leaves of Cinnamomum wightii Meisner, Garcinia gummi-gutta (L.) Robs., Michelia nilagrica Zenk. Tylophora indica (Burm. f.) Merr., Hemidesmus indicus (L.) R. Br. and Gymnema sylvestre (Retz.) R. Br. ex Schult may be a promising source of novel anticancer agents.
 
Key words: Brine shrimp lethality, cytotoxic, medicinal plants

 

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ISSN: 2231-0436 (Print)

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